[DOWNLOAD] "Pharmacological and Toxicological Activity of Heterophyllaea Pustulata Anthraquinone Extracts." by Phytomedicine: International Journal of Phytotherapy & Phytopharmacology # eBook PDF Kindle ePub Free

📘 Read Now     📥 Download

eBook details

• Title: Pharmacological and Toxicological Activity of Heterophyllaea Pustulata Anthraquinone Extracts.
• Author : Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
• Release Date : January 01, 2003
• Genre: Life Sciences,Books,Science & Nature,
• Pages : * pages
• Size : 210 KB

Description

Summary Benzenic extracts from both stems and leaves of Heterophyllaea pustulata showed the most significant activity in vivo in the Brine Shrimp Lethally Test (BST), relative to others of different polarity. They were therefore selected for in vitro antimicrobial activity studies. Bacteriostatic activity against Micrococcus luteus ATCC 9341 was detected, selectively inhibiting both oxacillin-sensitive and-resistant Staphylococcus aureus, among several Gram-positive and Gram-negative bacterial species tested. Antifungal activity against important opportunist microorganisms and against those involved in superficial mycosis, all from nosocomial origin was also detected. A chemical screening revealed the presence of anthraquinones as major compounds. Among them, we identified damnacanthal, rubiadin, 2-hydroxy-3-methyl anthraquinone, soranjidiol, rubiadin-1-methyl ether, and damnacanthol in the benzenic stem extract. The benzenic leaf extract shows a similar chemical composition, except for damnacanthal, damnacanthol, soranjidiol-1-methyl ether, and 3 anthraqninones whose structures have not yet been elucidated. Acute toxicity studies revealed a low toxicity in mice for the anthraqninonic extracts, as measured in the L[D.sub.50] value (123 mg/kg body wt. i.v.), and death was not observed at doses of up to 4000 mg/kg body wt. s.c.

Download Books "Pharmacological and Toxicological Activity of Heterophyllaea Pustulata Anthraquinone Extracts." PDF ePub Kindle